The history of the city of Agrinio is closely connected to tobacco. Thus, the tobacco factories are buildings of great historical, architectural and cultural value.

The tobacco factories in Agrinio were designed in order to best serve their function: as there was need for light during the tobacco processing and shadow for the tobacco storage, the buildings were designed to provide plenty of light in the upper level and shadow in the lower level. The unprocessed tobacco leafs were stored on wooden frames on the first floor, where there was enough air circulation to protect them from rotting. Around the walls of the first floor there were small windows, big enough to allow air in and small enough to eliminate light. The tobacco processing took place on the second floor, where there were large windows allowing plenty of light inside the room.

The interior of the tobacco factories is a large single room with wooden roofs covered by Byzantine tiles.

A characteristic of all these buildings was that they only had one relatively small entrance door.