The Church of Agrinio is under the authority of the Holy Metropolis of Aitolia & Akarnania, which has its headquarters in Mesologgi.

Aghios Christoforos is the protector Saint of Agrinio. There are two temples dedicated to him in the city.

The old temple of Aghios Christoforos was built in 1847 and is located in the park north from the city, while the new temple was founded in 1920 and the opening ceremony was in 1937. His memory is celebrated on May 9 and this day is a holiday in Agrinio and a religious celebration takes place.

The Holy Metropolis in Agrinio has founded orphanages, a Byzantine music school, bookstores, and is involved in many other social, religious and cultural activities.

The most important temples of the Municipality of Agrinio are listed below:

Old Temples

• The Older Holy Temple of Aghios Christoforos
• Aghia Triada of Mavrikas
• The Chapel of Ai-Lia (saint Elias) in the lake of Trichonida
• The Chapel of Aghia Marina
• The Byzantine Church in the village of Vlochos
• The Church of Panaghia (Virgin Mary) in Meghali Chora

New Temples

• The New Holy Temple of Aghios Christoforos
• The New Holy Temple of Aghios Dimitrios
• The Holy Temple of Aghios Georgios
• The Holy Temple of Aghia Triada
• The Holy Temple of Evaggelistria
• The Holy Temple of Zoodochos Pigi
• The Holy Temple of Prophet Elias